These clinical trials are designed to study vision-related issues in multiple sclerosis.


Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis


Purpose: Primary fatigue represents a major cause of disability in patients with multiple sclerosis (MS), being reported in about 90% of cases. Fatigue interferes with everyday functioning but, unfortunately, little is known about its mechanisms. The investigators propose a characteristic eye movement abnormality (internuclear ophthalmoparesis, INO), commonly encountered in MS, as a simple model for primary motor fatigue. The investigators described worsening of ocular performance in MS patients with INO following visual tasks (ocular motor fatigue), which is likely due to decreased neural conduction along brain pathways injured by MS. This mechanism could represent a major component of MS-related primary motor fatigue.

Rationale: Relevant to Veterans’ care, INO is a significant cause of visual disability, especially when complicated by ocular fatigue, and limits daily activities such as reading and driving. The investigators propose a medical treatment to improve ocular performance/fatigue in INO, which can reduce visual disability and improve quality of life in Veterans with MS.

Eligibility: Age 18 to 65, male or female, with a diagnosis of MS of any course and duration, and evidence of mild to moderate internuclear opthalmoparesis (INO). Further enrollment criteria are available at:

Sponsor:  VA Office of Research and Development                   

Contact: Alessandro Serra, MD, PhD (216) 791-3800 ext. 5218,



Vestibular Rehabilitation for Persons with Multiple Sclerosis: Who Benefits Most? (MSVR3 Trial)



Purpose: To advance our knowledge of the effect of vestibular rehabilitation for persons with MS in a larger study identifying persons with MS who have brain lesion involvement in areas that control balance and eye movement.



Eligibility: A diagnosis of MS, 18–60 years old, reporting moderate fatigue and impaired balance. Further eligibility criteria are at:



Study Design: Participants who are randomized to the experimental group will perform 1-hour supervised intervention sessions 2 times/week for 6-weeks, then 1 time/week for 8-weeks, for a total of 20 supervised sessions. The intervention is a progressive vestibular rehabilitation program comprised of balance and eye movement exercises as detailed in our preliminary study report.


Study Outcomes: Balance, visual stability, perceived fatigue. 


Sponsor: University of Colorado, Denver; National Multiple Sclerosis Society


Contact:  Maggie Reineke, (303) 724-4717,; Jeffrey Hebert, (303) 724-9595,